I picked up Sins of a Solar Empire over the weekend, and it's quite good. It's the modern day equivalent to Master of Orion, or the lesser known Imperium Galactica. Highly recommended for fans of the genre. The gameplay is massive and immersive. Multiplayer matches can range from a short skirmish battle, to epic campaigns that can take weeks in real time to complete. Luckily, multiplayer games have a save option.
If anyone is playing it, let me know, and we can set up a multiplayer match; up to 10 players are supported.